Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients

Gene. 2015 Oct 25;571(2):249-51. doi: 10.1016/j.gene.2015.06.068. Epub 2015 Jun 27.

Abstract

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in Chinese pediatric patients. To date, the genetic susceptibility to AD in this population has not been fully clarified. Three single nucleotide polymorphisms have previously been associated with AD in Europeans, rs2897442 (KIF3A), rs479844 (OVOL1) and rs2164983 (ACTL9). To verify the correlation between AD and these three SNPs in the Chinese pediatric population, we conducted a case-control study including 235 pediatric patients with AD and 200 health controls. We confirmed the correlation between rs2897442 and rs479844 and AD in this population at both the genotype and allele levels. Statistical analysis showed that the C allele of rs2897442 is associated with an increased risk of developing AD, while the A allele of rs479844 is associated with a reduced risk. No correlation between rs2164983 and AD was identified. Our study indicates that KIF3A and OVOL1 are involved in the development of AD in the Chinese pediatric population.

Keywords: ACTL9; Atopic dermatitis; KIF3A; OVOL1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / genetics*
  • Adolescent
  • Asian People / genetics
  • Case-Control Studies
  • Child
  • China / epidemiology
  • DNA-Binding Proteins / genetics*
  • Dermatitis, Atopic / epidemiology
  • Dermatitis, Atopic / genetics*
  • Female
  • Gene Frequency
  • Humans
  • Kinesins / genetics*
  • Male
  • Polymorphism, Single Nucleotide
  • Transcription Factors / genetics*

Substances

  • ACTL9 protein, human
  • Actins
  • DNA-Binding Proteins
  • KIF3A protein, human
  • OVOL1 protein, human
  • Transcription Factors
  • Kinesins