Thiazide Diuretics in the Management of Young Children with Central Diabetes Insipidus

J Pediatr. 2015 Sep;167(3):658-61. doi: 10.1016/j.jpeds.2015.06.002. Epub 2015 Jun 27.


Objective: To report our experience in treating infants and toddlers with central diabetes insipidus (DI) with thiazide diuretics.

Study design: A retrospective chart review of all infants and toddlers who were treated with thiazide diuretics for central DI at the Mayo Clinic between 1996 and 2014.

Results: Our cohort consisted of 13 patients. The median age at the start of therapy was 6 months (IQR, 1-14 months). Eight patients were given chlorothiazide at a starting dose of 5-10 mg/kg/day, and 5 patients were treated with hydrochlorothiazide at a starting dose of 1-2 mg/kg/day. The median age at the cessation of thiazide therapy was 18 months (IQR, 11.5-39 months). The main reason for stopping was the lack of continued response, in addition to hypernatremia. There was no hospitalization secondary to hyponatremia and only 1 hospitalization secondary to hypernatremia while receiving thiazide therapy. Calcium was checked periodically in 7 of the 13 patients, and 2 of these 7 patients had persistent hypercalcemia.

Conclusion: Thiazide diuretics appear to be safe and effective in treating infants with central DI. They can be continued after the introduction of solid food, and until a lack of response is observed.

MeSH terms

  • Blood Glucose / analysis
  • Calcium / blood
  • Chlorothiazide / therapeutic use
  • Diabetes Insipidus, Neurogenic / drug therapy*
  • Female
  • Humans
  • Hydrochlorothiazide / therapeutic use
  • Infant
  • Infant, Newborn
  • Male
  • Potassium / blood
  • Retrospective Studies
  • Sodium Chloride Symporter Inhibitors / therapeutic use*


  • Blood Glucose
  • Sodium Chloride Symporter Inhibitors
  • Hydrochlorothiazide
  • Chlorothiazide
  • Potassium
  • Calcium