Soluble RAGEs - Prospects for treating & tracking metabolic and inflammatory disease

Vascul Pharmacol. 2015 Sep;72:1-8. doi: 10.1016/j.vph.2015.06.011. Epub 2015 Jun 27.


Emerging evidence links the receptor for advanced glycation endproducts (RAGE) to the pathogenesis of tissue damage in chronic metabolic and inflammatory diseases. In human subjects, multiple reports suggest that in the plasma/serum, circulating levels of distinct forms of soluble RAGEs may be biomarkers of the presence or absence, and the extent of chronic disease. These considerations prompt us to consider in this review, what are soluble RAGEs; how are they formed; what might be their natural functions; and may they serve as biomarkers of inflammatory and metabolic disease activity? In this brief review, we seek to address what is known and suggest new areas for scientific investigation to uncover the biology of soluble RAGEs.

Keywords: Soluble RAGE.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers / blood
  • Humans
  • Inflammation / blood*
  • Metabolic Diseases / blood*
  • Receptor for Advanced Glycation End Products / blood*


  • Biomarkers
  • Receptor for Advanced Glycation End Products