The evaluation of inflammatory and oxidative stress biomarkers on coffee-diabetes association: results from the 10-year follow-up of the ATTICA Study (2002-2012)

Eur J Clin Nutr. 2015 Nov;69(11):1220-5. doi: 10.1038/ejcn.2015.98. Epub 2015 Jul 1.

Abstract

Background/objectives: The purpose of this work was to investigate the association between coffee drinking and diabetes development and potential mediation by oxidative stress and inflammatory biomarkers.

Subjects/methods: In 2001-2002, a random sample of 1514 men (18-87 years old) and 1528 women (18-89 years old) were selected to participate in the ATTICA study (Athens metropolitan area, Greece). A validated food-frequency questionnaire was used to assess coffee drinking (abstention, casual, habitual) and other lifestyle and dietary factors. Evaluation of oxidative stress and inflammatory markers was also performed. During 2011-2012, the 10-year follow-up of the ATTICA study was carried out. The outcome of interest in this work was incidence of type 2 diabetes, defined according to American Diabetes Association criteria.

Results: During follow-up, 191 incident cases of diabetes were documented (incidence 13.4% in men and 12.4% in women). After various adjustments, individuals who consumed ⩾250 ml of coffee (≈1.5cup) had 54% lower odds of developing diabetes (95% confidence interval: 0.24, 0.90), as compared with abstainers. A dose-response linear trend between coffee drinking and diabetes incidence was also observed (P for trend=0.017). When controlling for several oxidative stress and inflammatory biomarkers, the inverse association between habitual coffee drinking and diabetes was found to be mediated by serum amyloid-A levels.

Conclusions: This work highlights the significance of long-term habitual coffee drinking against diabetes onset. The anti-inflammatory effect of several coffee components may be responsible for this protection.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Coffee* / chemistry
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / pathology
  • Diabetes Mellitus, Type 2 / prevention & control*
  • Diet / adverse effects*
  • Feeding Behavior*
  • Female
  • Follow-Up Studies
  • Greece / epidemiology
  • Humans
  • Incidence
  • Inflammation / blood*
  • Life Style
  • Male
  • Middle Aged
  • Oxidative Stress*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Risk Factors
  • Serum Amyloid A Protein / metabolism*
  • Surveys and Questionnaires
  • Young Adult

Substances

  • Biomarkers
  • Coffee
  • Plant Extracts
  • Serum Amyloid A Protein