'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung

Thorax. 2015 Nov;70(11):1092-4. doi: 10.1136/thoraxjnl-2015-207035. Epub 2015 Jun 30.


We developed LungGENS (Lung Gene Expression iN Single-cell), a web-based bioinformatics resource for querying single-cell gene expression databases by entering a gene symbol or a list of genes or selecting a cell type of their interest. Gene query provides quantitative RNA expression of the gene of interest in each lung cell type. Cell type query returns associated selective gene signatures and genes encoding cell surface markers and transcription factors in interactive heatmap and tables. LungGENS will be broadly applicable in respiratory research, providing a cell-specific RNA expression resource at single-cell resolution. LungGENS is freely available for non-commercial use at https://research.cchmc.org/pbge/lunggens/default.html.

Keywords: Airway Epithelium; Surfactant protein; Systemic disease and lungs; TTF-1.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Chromosome Mapping
  • Computational Biology / methods*
  • Gene Expression Profiling / methods*
  • Gene Expression*
  • Humans
  • Internet*
  • Lung / growth & development*
  • Lung / metabolism
  • Software
  • Transcription Factors


  • Transcription Factors