Viral Load in Infants Hospitalized for Respiratory Syncytial Virus Bronchiolitis Correlates with Recurrent Wheezing at Thirty-Six-Month Follow-Up

Pediatr Infect Dis J. 2015 Oct;34(10):1131-2. doi: 10.1097/INF.0000000000000825.


The relationship between viral infection, host immune response in infants with respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing is discussed. We measured RSV-RNA load and interferon-λ1-3 expression in the nasopharyngeal washings from 68 infants hospitalized for RSV bronchiolitis, and wheezing was assessed 36 months after the first episode of bronchiolitis. Higher RSV-RNA load and higher interferon-λ2/3 levels were found in children with recurrent wheezing at 36-month follow-up.

MeSH terms

  • Bronchiolitis, Viral / epidemiology*
  • Bronchiolitis, Viral / genetics
  • Bronchiolitis, Viral / physiopathology
  • Bronchiolitis, Viral / virology*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Interferon-gamma / analysis
  • Interferon-gamma / genetics
  • Interferon-gamma / metabolism
  • Male
  • Respiratory Sounds / physiopathology*
  • Respiratory Syncytial Virus Infections / epidemiology*
  • Respiratory Syncytial Virus Infections / genetics
  • Respiratory Syncytial Virus Infections / physiopathology
  • Respiratory Syncytial Virus Infections / virology*
  • Respiratory Syncytial Virus, Human
  • Retrospective Studies
  • Viral Load


  • Interferon-gamma