A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum

Molecules. 2015 Jun 26;20(7):11765-76. doi: 10.3390/molecules200711765.


Multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. The antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Nannizzia cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Arthroderma gypseum, Trichophyton rubrum and Trichophyton tonsurans. α-Bisabolol showed the best antifungal activity against all fungi and in particular; against M. gypseum. Further investigations were conducted on this fungus to evaluate the inhibition of spore germination and morphological changes induced by α-bisabolol by TEM.

Keywords: M. gypseum; TEM; antifungal activity; dermatophytes; skin lightener; α-bisabolol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthrodermataceae / drug effects*
  • Arthrodermataceae / growth & development
  • Arthrodermataceae / ultrastructure
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Transmission
  • Microsporum / drug effects*
  • Microsporum / growth & development
  • Microsporum / ultrastructure
  • Monocyclic Sesquiterpenes
  • Sesquiterpenes / pharmacology*
  • Spectrophotometry, Ultraviolet
  • Spores, Fungal / drug effects


  • Monocyclic Sesquiterpenes
  • Sesquiterpenes
  • bisabolol