The innate immune response in human tuberculosis

Cell Microbiol. 2015 Sep;17(9):1277-85. doi: 10.1111/cmi.12480. Epub 2015 Jul 28.


Mycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini-review, we discuss these host-pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome-wide association studies).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Genome-Wide Association Study
  • Host-Pathogen Interactions*
  • Humans
  • Immune Evasion
  • Immunity, Innate*
  • Mycobacterium tuberculosis / immunology*
  • Tuberculosis / immunology*