Correlation of Cu(PTSM) localization with regional blood flow in the heart and kidney

Int J Rad Appl Instrum B. 1989;16(7):747-8. doi: 10.1016/0883-2897(89)90149-9.


In a dog model of myocardial ischemia, i.v. injection of [67Cu]Cu(PTSM) leads to an excellent linear correlation for both the heart and kidney between regional tissue radiocopper concentration and regional blood flow measured by radioactive micropheres. The 62Cu-labeled complex may serve as a generator-produced position-emitting perfusion tracer for these organs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Copper Radioisotopes
  • Coronary Circulation*
  • Dogs
  • Heart / diagnostic imaging*
  • Kidney / diagnostic imaging*
  • Microspheres
  • Organometallic Compounds*
  • Radionuclide Imaging
  • Renal Circulation*
  • Strontium Radioisotopes
  • Thiosemicarbazones*


  • Copper Radioisotopes
  • Organometallic Compounds
  • Strontium Radioisotopes
  • Thiosemicarbazones
  • copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex