Roles of A20 in autoimmune diseases

Immunol Res. 2016 Apr;64(2):337-44. doi: 10.1007/s12026-015-8677-6.


A20 (TNFAIP3), known to inhibit NF-κB function by deubiquitinating-specific NF-κB signaling molecules, has been found in many cell types of the immune system. Recent findings suggest that A20 is essential for the development and functional performance of dendritic cell, B cell, T cell and macrophage. A number of studies further demonstrate that these cells are crucial in the pathogenesis of autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, inflammatory bowel disease, ankylosing arthritis, Sjögren's syndrome and rheumatoid arthritis. In this article, we focus on the recent advances on the roles of A20 in autoimmune diseases and discuss the therapeutic significance of these new findings.

Keywords: A20 (TNFAIP3); Autoimmune diseases; Autoimmunity; Immune cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / metabolism*
  • Autoimmunity
  • Cell Differentiation
  • Cytokines / metabolism
  • Gene Expression
  • Gene Expression Regulation
  • Humans
  • Immune System / cytology
  • Immune System / immunology
  • Immune System / metabolism
  • Signal Transduction
  • Tumor Necrosis Factor alpha-Induced Protein 3 / genetics
  • Tumor Necrosis Factor alpha-Induced Protein 3 / metabolism*


  • Cytokines
  • TNFAIP3 protein, human
  • Tumor Necrosis Factor alpha-Induced Protein 3