Promoting metastasis: neutrophils and T cells join forces

Cell Res. 2015 Jul;25(7):765-6. doi: 10.1038/cr.2015.62. Epub 2015 May 26.


The role neutrophils play in cancer is a matter of debate as both pro- and anti-tumor functions have been documented. In a recent publication in Nature, Coffelt et al. identify a new mechanism where neutrophils and T cells cooperate to generate metastasis-supporting immune suppression.

Publication types

  • Comment

MeSH terms

  • Animals
  • Breast Neoplasms / pathology*
  • Female
  • Interleukin-17 / biosynthesis*
  • Neoplasm Metastasis / immunology*
  • Neoplasm Metastasis / pathology*
  • Neutrophils / metabolism*
  • T-Lymphocyte Subsets / metabolism*


  • Interleukin-17