Successful long-term ambulatory norepinephrine infusions in a patient with pure autonomic failure

Clin Auton Res. 2015 Aug;25(4):251-3. doi: 10.1007/s10286-015-0290-1. Epub 2015 Jul 3.


We present a case study of a patient with pure autonomic failure who was successfully treated with ambulatory norepinephrine (NE) infusions over a 9-year-period of time before death occurred unexpectedly. Given this patient's response to the NE infusion treatment, we discuss the option of ambulatory NE infusions as a treatment for severe orthostatic hypotension that is refractory to common treatments.

Keywords: Norepinephrine infusions; PAF; Pure autonomic failure.

Publication types

  • Case Reports

MeSH terms

  • Ambulatory Care / methods*
  • Fatal Outcome
  • Humans
  • Hypotension, Orthostatic / diagnosis*
  • Hypotension, Orthostatic / drug therapy*
  • Hypotension, Orthostatic / physiopathology
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Norepinephrine / administration & dosage*
  • Pure Autonomic Failure / diagnosis*
  • Pure Autonomic Failure / drug therapy*
  • Pure Autonomic Failure / physiopathology
  • Time Factors


  • Norepinephrine