Dissecting the Role of Smooth Muscle Cells versus Pericytes in Regulating Cerebral Blood Flow Using In Vivo Optical Imaging

Jenna Mazzoni; Tyler Cutforth; Dritan Agalliu

doi:10.1016/j.neuron.2015.06.024

Dissecting the Role of Smooth Muscle Cells versus Pericytes in Regulating Cerebral Blood Flow Using In Vivo Optical Imaging

Neuron. 2015 Jul 1;87(1):4-6. doi: 10.1016/j.neuron.2015.06.024.

Authors

Jenna Mazzoni¹, Tyler Cutforth², Dritan Agalliu³

Affiliations

¹ Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
² Departments of Neurology and Pathology & Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
³ Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA; Departments of Neurology and Pathology & Cell Biology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: da191@cumc.columbia.edu.

PMID: 26139364
DOI: 10.1016/j.neuron.2015.06.024

Abstract

The brain regulates blood flow to match energy demand to nutrient supply. In this issue of Neuron, using in vivo optical imaging and optogenetics, Hill et al. (2015) report that arteriolar smooth muscle cells are key players in regulating cerebral blood flow in the healthy state and contribute to the "no reflow" phenomenon after ischemic stroke.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Brain Ischemia*
Cerebral Cortex / blood supply*
Cerebrovascular Circulation / physiology*
Humans
Muscle Contraction / physiology*
Myocytes, Smooth Muscle / physiology*
Pericytes / physiology*

Abstract

Publication types

MeSH terms

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