Biochemical Computation for Spine Structural Plasticity

Neuron. 2015 Jul 1;87(1):63-75. doi: 10.1016/j.neuron.2015.05.043.


The structural plasticity of dendritic spines is considered to be essential for various forms of synaptic plasticity, learning, and memory. The process is mediated by a complex signaling network consisting of numerous species of molecules. Furthermore, the spatiotemporal dynamics of the biochemical signaling are regulated in a complicated manner because of geometrical restrictions from the unique morphology of the dendritic branches and spines. Recent advances in optical techniques have enabled the exploration of the spatiotemporal aspects of the signal regulations in spines and dendrites and have provided many insights into the principle of the biochemical computation that underlies spine structural plasticity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review
  • Video-Audio Media

MeSH terms

  • Dendrites / physiology
  • Dendritic Spines / physiology*
  • Humans
  • Learning / physiology*
  • Long-Term Potentiation
  • Neuronal Plasticity / physiology*
  • Signal Transduction