Direct Reprogramming of RESTing Astrocytes

Cell Stem Cell. 2015 Jul 2;17(1):1-3. doi: 10.1016/j.stem.2015.06.011.


Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determination and identify circuits that mediate cellular identity.

Publication types

  • Comment

MeSH terms

  • Animals
  • Astrocytes / cytology*
  • Astrocytes / metabolism*
  • Cellular Reprogramming / physiology*
  • Humans
  • Repressor Proteins / metabolism*


  • Repressor Proteins