Platelets and Their Interactions with Other Immune Cells

Compr Physiol. 2015 Jul 1;5(3):1265-80. doi: 10.1002/cphy.c140074.


Platelets are anucleate blood cells, long known to be critically involved in hemostasis and thrombosis. In addition to their role in blood clots, increasing evidence reveals significant roles for platelets in inflammation and immunity. However, the notion that platelets represent immune cells is not broadly recognized in the field of Physiology. This article reviews the role of platelets in inflammation and immune responses, and highlights their interactions with other immune cells, including examples of major functional consequences of these interactions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Blood Platelets / immunology*
  • Chemokines / genetics
  • Chemokines / metabolism
  • Cytokines / genetics
  • Cytokines / metabolism
  • Humans
  • Leukocytes / immunology
  • Thrombosis / immunology*
  • Toll-Like Receptors / genetics
  • Toll-Like Receptors / metabolism


  • Chemokines
  • Cytokines
  • Toll-Like Receptors