Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes

Integr Comp Biol. 2015 Sep;55(3):478-85. doi: 10.1093/icb/icv077. Epub 2015 Jul 2.


This review provides an overview of two complementary approaches to identify biologically active compounds for studies in chemical ecology. The first is activity-guided fractionation and the second is metabolomics, particularly focusing on a new liquid chromatography-mass spectrometry-based method called isotopic ratio outlier analysis. To illustrate examples using these approaches, we review recent experiments using Caenorhabditis elegans and related free-living nematodes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biological Products / metabolism*
  • Caenorhabditis elegans / physiology
  • Chemical Fractionation / methods*
  • Chemotaxis*
  • Chromatography, Liquid
  • Mass Spectrometry
  • Metabolomics / methods*
  • Nematoda / physiology*


  • Biological Products