Cutaneous Manifestations of Crohn Disease

Dermatol Clin. 2015 Jul;33(3):417-31. doi: 10.1016/j.det.2015.03.007.


Awareness of the extraintestinal manifestations of Crohn disease is increasing in dermatology and gastroenterology, with enhanced identification of entities that range from granulomatous diseases recapitulating the underlying inflammatory bowel disease to reactive conditions and associated dermatoses. In this review, the underlying etiopathology of Crohn disease is discussed, and how this mirrors certain skin manifestations that present in a subset of patients is explored. The array of extraintestinal manifestations that do not share a similar pathology, but which are often seen in association with inflammatory bowel disease, is also discussed. Treatment and pathogenetic mechanisms, where available, are discussed.

Keywords: Crohn disease; Cutaneous Crohn disease; Extraintestinal manifestations; Inflammatory bowel disease.

Publication types

  • Review

MeSH terms

  • Crohn Disease / complications
  • Crohn Disease / drug therapy
  • Crohn Disease / pathology*
  • Erythema Nodosum / drug therapy
  • Erythema Nodosum / etiology
  • Erythema Nodosum / pathology
  • Granulomatosis, Orofacial / drug therapy
  • Granulomatosis, Orofacial / etiology
  • Granulomatosis, Orofacial / pathology
  • Humans
  • Lymphedema / drug therapy
  • Lymphedema / etiology
  • Lymphedema / pathology
  • Pyoderma Gangrenosum / drug therapy
  • Pyoderma Gangrenosum / etiology
  • Pyoderma Gangrenosum / pathology
  • Skin Diseases / drug therapy
  • Skin Diseases / etiology
  • Skin Diseases / pathology*
  • Sweet Syndrome / drug therapy
  • Sweet Syndrome / etiology
  • Sweet Syndrome / pathology
  • Vasculitis, Leukocytoclastic, Cutaneous / drug therapy
  • Vasculitis, Leukocytoclastic, Cutaneous / etiology
  • Vasculitis, Leukocytoclastic, Cutaneous / pathology