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Randomized Controlled Trial
, 76, 37-41

Marine n-3 Polyunsaturated Fatty Acids Lower Plasma Proprotein Convertase Subtilisin Kexin Type 9 Levels in Pre- And Postmenopausal Women: A Randomised Study

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Randomized Controlled Trial

Marine n-3 Polyunsaturated Fatty Acids Lower Plasma Proprotein Convertase Subtilisin Kexin Type 9 Levels in Pre- And Postmenopausal Women: A Randomised Study

Christina B Graversen et al. Vascul Pharmacol.

Abstract

Objective: To investigate whether a supplement of 2.2g of marine n-3 polyunsaturated fatty acids (PUFA) influences plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels in pre- and postmenopausal women.

Methods: Ninety-two healthy women were randomly assigned to consume 2.2g marine n-3 PUFA or a control oil (thistle oil) daily for 12 weeks. Adipose tissue, a long-term marker of dietary intake of seafood was collected at baseline and blood samples were drawn at baseline and after 12 weeks of supplement intake.

Results: Plasma PCSK9 levels were significantly reduced by 11.4% for premenopausal women and 9.8% for postmenopausal women after the supplement of 2.2g of marine n-3 PUFA compared with control oil. The mean change of plasma PCSK9 levels between participants receiving marine n-3 PUFA and control oil was 16.1% for premenopausal women and 13.1% for postmenopausal women. There was, however, no correlation between baseline levels of plasma PCSK9 and the fatty acid content of marine n-3 PUFA in adipose tissue.

Conclusion: This study showed that 2.2g marine n-3 PUFA reduce plasma PCSK9 levels in both pre- and postmenopausal women.

Keywords: Adipose tissue; Diet; Fatty acids; Fish oils; PCSK9.

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