X-ray crystal structure of acrovestone, a cytotoxic principle from Acronychia pedunculata

T S Wu; M L Wang; T T Jong; A T McPhail; D R McPhail; K H Lee

doi:10.1021/np50066a014

X-ray crystal structure of acrovestone, a cytotoxic principle from Acronychia pedunculata

J Nat Prod. 1989 Nov-Dec;52(6):1284-9. doi: 10.1021/np50066a014.

Authors

T S Wu¹, M L Wang, T T Jong, A T McPhail, D R McPhail, K H Lee

Affiliation

¹ Department of Applied Chemistry, Providence College of Arts and Science, Taichung Hsien, Taiwan, Republic of China.

PMID: 2614422
DOI: 10.1021/np50066a014

Abstract

Acrovestone was isolated from the stem and root back of Acronychia pedunculata and shown for the first time to be a cytotoxic principle. Its structure, derived from spectral data, was completely characterized by single-crystal X-ray analysis.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Acetophenones / isolation & purification*
Acetophenones / pharmacology
Antineoplastic Agents, Phytogenic / isolation & purification*
Crystallography
Culture Techniques
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Plants, Medicinal / analysis*

Substances

Acetophenones
Antineoplastic Agents, Phytogenic
acrovestone

Grants and funding

CA-17625/CA/NCI NIH HHS/United States