De novo synthesis of phenolic dihydroxanthene near-infrared emitting fluorophores

Org Biomol Chem. 2015 Aug 14;13(30):8169-72. doi: 10.1039/c5ob01223f.

Abstract

We report a flexible de novo synthesis of phenolic dihydroxanthene fluorophores. The synthesis relies on a one-pot formation of an aldehyde intermediate which can be diversified in 60-70% overall yield, providing an efficient access to this family of near-infrared emitting fluorophores.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Phenols / chemical synthesis*
  • Phenols / chemistry
  • Spectroscopy, Near-Infrared*
  • Xanthenes / chemical synthesis*
  • Xanthenes / chemistry

Substances

  • Fluorescent Dyes
  • Phenols
  • Xanthenes