Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Aug 11;51(62):12427-30.
doi: 10.1039/c5cc04500b.

The Amido-Pentadienoate-Functionality of the Rakicidins Is a Thiol Reactive Electrophile--Development of a General Synthetic Strategy

Affiliations

The Amido-Pentadienoate-Functionality of the Rakicidins Is a Thiol Reactive Electrophile--Development of a General Synthetic Strategy

Lise L Clement et al. Chem Commun (Camb). .

Abstract

We demonstrate that a unique class-defining functionality (mc-APD) found in macrocyclic natural products with potent anti-cancer activity, imparts these compounds with electrophilic reactivity. The mc-APD group represents an interesting structural hybrid between canonical biologically relevant Michael-acceptors. Further, a novel thiol-elimination method for preparation of the mc-APD group is outlined.

Similar articles

See all similar articles

Cited by 2 articles

Publication types

MeSH terms

LinkOut - more resources

Feedback