Antioxidant activity of taxifolin: an activity-structure relationship

J Enzyme Inhib Med Chem. 2016 Aug;31(4):674-83. doi: 10.3109/14756366.2015.1057723. Epub 2015 Jul 6.


Taxifolin is a kind of flavanonol, whose biological ability. The objectives of this study were to investigate the antioxidants and antiradical activities of taxifolin by using different in vitro bioanalytical antioxidant methods including DMPD√(+), ABTS√(+), [Formula: see text], and DPPH√-scavenging effects, the total antioxidant influence, reducing capabilities, and Fe(2+)-chelating activities. Taxifolin demonstrated 81.02% inhibition of linoleic acid emulsion peroxidation at 30 µg/mL concentration. At the same concentration, standard antioxidants including trolox, α-tocopherol, BHT, and BHA exhibited inhibitions of linoleic acid emulsion as 88.57, 73.88, 94.29, and 90.12%, respectively. Also, taxifolin exhibited effective DMPD√(+), ABTS√(+), [Formula: see text], and DPPH√-scavenging effects, reducing capabilities, and Fe(2+)-chelating effects. The results obtained from this study clearly showed that taxifolin had marked antioxidant, reducing ability, radical scavenging and metal-chelating activities. Also, this study exhibits a scientific shore for the significant antioxidant activity of taxifolin and its structure-activity insight.

Keywords: Antioxidant activity; radical scavenging; structure–activity insight; taxifolin.

MeSH terms

  • Antioxidants / chemistry*
  • Antioxidants / pharmacology*
  • Dose-Response Relationship, Drug
  • Free Radicals / antagonists & inhibitors
  • Free Radicals / chemistry
  • Lipid Peroxidation / drug effects
  • Quercetin / analogs & derivatives*
  • Quercetin / chemistry
  • Quercetin / pharmacology
  • Spectrophotometry
  • Structure-Activity Relationship


  • Antioxidants
  • Free Radicals
  • Quercetin
  • taxifolin