Road blocks in making platelets for transfusion

J N Thon; D A Medvetz; S M Karlsson; J E Italiano Jr

doi:10.1111/jth.12942

Road blocks in making platelets for transfusion

J Thromb Haemost. 2015 Jun;13 Suppl 1(Suppl 1):S55-62. doi: 10.1111/jth.12942.

Authors

J N Thon^{1

2

3}, D A Medvetz^{1

2}, S M Karlsson³, J E Italiano Jr^{1

2

3}

Affiliations

¹ Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
² Harvard Medical School, Boston, MA, USA.
³ Platelet BioGenesis, Chestnut Hill, MA, USA.

Abstract

The production of laboratory-generated human platelets is necessary to meet present and future transfusion needs. This manuscript will identify and define the major roadblocks that must be overcome to make human platelet production possible for clinical use, and propose solutions necessary to accelerate development of laboratory-generated human platelets to market.

Keywords: biomedical engineering; bioreactors; hematopoietic stem cells; megakaryocytes; platelets.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Bioreactors
Blood Platelets / physiology*
Cell Culture Techniques / instrumentation
Cells, Cultured
Cellular Reprogramming
Gene Expression Regulation, Developmental
Humans
Induced Pluripotent Stem Cells / physiology*
Megakaryocytes / physiology*
Phenotype
Platelet Transfusion*
Stem Cell Niche
Thrombopoiesis* / genetics

Abstract

Publication types

MeSH terms

Grants and funding