Road blocks in making platelets for transfusion

J Thromb Haemost. 2015 Jun;13 Suppl 1(Suppl 1):S55-62. doi: 10.1111/jth.12942.


The production of laboratory-generated human platelets is necessary to meet present and future transfusion needs. This manuscript will identify and define the major roadblocks that must be overcome to make human platelet production possible for clinical use, and propose solutions necessary to accelerate development of laboratory-generated human platelets to market.

Keywords: biomedical engineering; bioreactors; hematopoietic stem cells; megakaryocytes; platelets.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bioreactors
  • Blood Platelets / physiology*
  • Cell Culture Techniques / instrumentation
  • Cells, Cultured
  • Cellular Reprogramming
  • Gene Expression Regulation, Developmental
  • Humans
  • Induced Pluripotent Stem Cells / physiology*
  • Megakaryocytes / physiology*
  • Phenotype
  • Platelet Transfusion*
  • Stem Cell Niche
  • Thrombopoiesis* / genetics