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. 2015 Jul 7;16(1):136.
doi: 10.1186/s13059-015-0704-3.

Enter Exitrons

Free PMC article

Enter Exitrons

Dorothee Staiger et al. Genome Biol. .
Free PMC article


Exitrons are exon-like introns located within protein-coding exons. Removal or retention of exitrons through alternative splicing increases proteome complexity and thus adds to phenotypic diversity.

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    1. Braunschweig U, Gueroussov S, Plocik AM, Graveley BR, Blencowe BJ. Dynamic integration of splicing within gene regulatory pathways. Cell. 2013;152:1252–1869. doi: 10.1016/j.cell.2013.02.034. - DOI - PMC - PubMed
    1. Staiger D, Brown JWS. Alternative splicing at the intersection of biological timing, development, and stress responses. Plant Cell. 2013;25:3640–3656. doi: 10.1105/tpc.113.113803. - DOI - PMC - PubMed
    1. Marquez Y, Höpfler M, Ayatollahi Z, Barta A, Kalyna M. Unmasking alternative splicing inside protein-coding exons defines exitrons and their role in proteome plasticity. Genome Res. 2015 - PMC - PubMed
    1. Ner-Gaon H, Halachmi R, Savaldi-Goldstein S, Rubin E, Ophir R, Fluhr R. Intron retention is a major phenomenon in alternative splicing in Arabidopsis. Plant J. 2004;39:877–885. doi: 10.1111/j.1365-313X.2004.02172.x. - DOI - PubMed
    1. Braunschweig U, Barbosa-Morais NL, Pan Q, Nachman EN, Alipanahi B, Gonatopoulos-Pournatzis T, et al. Widespread intron retention in mammals functionally tunes transcriptomes. Genome Res. 2014;24:1774–1786. doi: 10.1101/gr.177790.114. - DOI - PMC - PubMed

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