The complex interplay of Depression, Inflammation and Omega-3: state of the art and progresses in research

Clin Ter. 2015;166(3):e242-7. doi: 10.7417/CT.2015.1859.


Many epidemiological and preclinical studies have proven the potential benefit and critical role of omega-3 PUFAs in the development and management of depressive disorders. Depression may be the consequence of a complex interplay between cell-mediated-immune activation and inflammation evolving in neuroprogression. Associations between n-3 PUFAs, inflammation, oxidative stress and the risk of depression have been demonstrated and clinical and animal supplementation studies have shown the potential of PUFAs to decrease neurodegeneration and inflammation. Future research should focus on the dynamic interactions between the different cell signaling networks and oxidative and nitrosative stress pathways that cause depression.

Keywords: Depression; Immunity; Inflammation; Omega-3; Oxidative stress; PUFAs.

Publication types

  • Review

MeSH terms

  • Animals
  • Depression / physiopathology*
  • Depressive Disorder / drug therapy
  • Fatty Acids, Omega-3 / pharmacology*
  • Humans
  • Inflammation / physiopathology*
  • Oxidative Stress / physiology
  • Risk


  • Fatty Acids, Omega-3