Moving Beyond "Lumpology": PET/CT Imaging of Pheochromocytoma and Paraganglioma

Michael S Hofman; Rodney J Hicks

doi:10.1158/1078-0432.CCR-15-1073

Moving Beyond "Lumpology": PET/CT Imaging of Pheochromocytoma and Paraganglioma

Clin Cancer Res. 2015 Sep 1;21(17):3815-7. doi: 10.1158/1078-0432.CCR-15-1073. Epub 2015 Jul 7.

Authors

Michael S Hofman¹, Rodney J Hicks¹

Affiliation

¹ Centre for Molecular Imaging and Neuroendocrine Tumour Service, Peter MacCallum Cancer Centre, Melbourne, Australia. Department of Medicine, University of Melbourne, Melbourne, Australia. michael.hofman@petermac.org rod.hicks@petermac.org.

PMID: 26152741
DOI: 10.1158/1078-0432.CCR-15-1073

Abstract

High somatostatin receptor expression on the cell membrane of succinate dehydrogenase mutation-related pheochromocytoma and paraganglioma provides a potential target for imaging and therapy. (68)Ga-DOTATATE positron emission PET/CT may represent a new gold standard for staging pheochromocytoma/paraganglioma and have future therapeutic implications.

Publication types

Comment

MeSH terms

Female
Humans
Male
Organometallic Compounds*
Paraganglioma / diagnosis*
Paraganglioma / genetics*
Pheochromocytoma / diagnosis*
Pheochromocytoma / genetics*
Positron-Emission Tomography*
Succinate Dehydrogenase / genetics*
Tomography, X-Ray Computed*

Substances

Organometallic Compounds
Succinate Dehydrogenase