Ethnopharmacologic investigation of ginger (Zingiber officinale)

J Ethnopharmacol. 1989 Nov;27(1-2):129-40. doi: 10.1016/0378-8741(89)90085-8.


An ethanolic extract of the rhizomes of Zingiber officinale was investigated for anti-inflammatory, analgesic, antipyretic, antimicrobial and hypoglycaemic activities. In rats, the extract reduced carrageenan-induced paw swelling and yeast-induced fever but was ineffective in suppressing the writhing induced by intraperitoneal acetic acid. The extract produced blood glucose lowering in rabbits. The growth of both Gram-positive and Gram-negative bacteria was significantly inhibited. A dose-dependent inhibition of prostaglandin release effect was observed using rat peritoneal leucocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Bacteria / drug effects
  • Hypoglycemic Agents
  • In Vitro Techniques
  • India
  • Leukocytes / drug effects
  • Leukocytes / metabolism
  • Male
  • Mice
  • Phagocytosis / drug effects
  • Plant Extracts / pharmacology
  • Plant Extracts / toxicity
  • Plants, Medicinal / analysis*
  • Prostaglandins / metabolism
  • Rats
  • Rats, Inbred Strains


  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Hypoglycemic Agents
  • Plant Extracts
  • Prostaglandins