Inspired by the unique microstructure of dentin, in which the hard peritubular dentin surrounding the dentin tubules is embedded in the soft intertubular dentin, we explore the crack propagation in the bioinspired materials with fracture process zone possessing a dentin-like microstructure, i.e. the composite structure consisting of a soft matrix and hard reinforcements with cylindrical voids. A micromechanical model under small-scale yielding conditions is developed, and numerical simulations are performed, showing that the rising resistant curve (R-curve) is observed for crack propagation caused by the plastic collapse of the intervoid ligaments in the fracture process zone. The dentin-like microstructure in the fracture process zone exhibits enhanced fracture toughness, compared with the case of voids embedded in the homogeneous soft matrix. Further computational simulations show that the dentin-like microstructure can retard void growth, thereby promoting fracture toughness. The typical fracture mechanism of the bioinspired materials with fracture process zone possessing the dentin-like structure is void by void growth, while it is the multiple void interaction in the case of voids in the homogeneous matrix. Based on the results, we propose a bioinspired material design principle, which is that the combination of a hard inner material encompassing voids and a soft outer material in the fracture process zone can give rise to exceptional fracture toughness, achieving damage tolerance. It is expected that the proposed design principle could shed new light on the development of novel man-made engineering materials.