Clinical insights by the presence of bipolar disorder in pseudohypoparathyroidism type 1A

Gen Hosp Psychiatry. 2015 Sep-Oct;37(5):497.e3-5. doi: 10.1016/j.genhosppsych.2015.06.008. Epub 2015 Jun 16.

Abstract

Pseudohypoparathyroidism type 1A and its association with bipolar disorder (BD) have never been reported so far. We report a new case with both clinical entities and discuss the potential pathophysiological mechanisms of this association (protein kinase A hypoactivation, parathyroid hormone, hypocalcemia, protein kinase C activation, vitamin D deficiency). In this patient, the correction of the underlying calcium and vitamin D deficiencies leads to a better BD outcome and lower dosage of psychopharmacological agents. The conclusions might be generalized for a better understanding and management of these conditions.

Keywords: Bipolar disorder; GNAS1 mutation; Pseudohypoparathyroidism type 1A; Vitamin D deficiency.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bipolar Disorder / complications*
  • Comorbidity
  • Female
  • Humans
  • Pseudohypoparathyroidism / complications*
  • Pseudohypoparathyroidism / physiopathology
  • Vitamin D Deficiency / complications