Metal-Free Direct Oxidation of Aldehydes to Esters Using TCCA

Org Lett. 2015 Aug 7;17(15):3666-9. doi: 10.1021/acs.orglett.5b01579. Epub 2015 Jul 10.

Abstract

Aromatic and aliphatic aldehydes are simply converted into esters by an efficient oxidative esterification carried out under mild conditions. The aldehydes are converted in situ into their corresponding acyl chlorides, which are then reacted with primary and secondary aliphatic, benzylic, allylic, and propargylic alcohols and phenols. A variety of esters are obtained in high yields.