Formaldehyde Exposure Alters miRNA Expression Profiles in the Olfactory Bulb

Inhal Toxicol. 2015;27(8):387-93. doi: 10.3109/08958378.2015.1062580. Epub 2015 Jul 10.

Abstract

It has been reported that inhaling formaldehyde (FA) causes damage to the central nervous system. However, it is unclear whether FA can disturb the function of the olfactory bulb. Using a microarray, we found that FA inhalation altered the miRNA expression profile. Functional enrichment analysis of the predicted targets of the changed miRNA showed that the enrichment canonical pathways and networks associated with cancer and transcriptional regulation. FA exposure disrupts miRNA expression profiles within the olfactory bulb.

Keywords: Formaldehyde; miRNA; olfactory bulb.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Animals
  • Formaldehyde / adverse effects
  • Formaldehyde / toxicity*
  • Male
  • Mice
  • Mice, Inbred ICR
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Olfactory Bulb / drug effects*
  • Oligonucleotide Array Sequence Analysis
  • Respiratory Hypersensitivity / chemically induced
  • Respiratory Hypersensitivity / pathology
  • Transcriptome*

Substances

  • MicroRNAs
  • Formaldehyde

Supplementary concepts

  • Formaldehyde poisoning