Abstract
With an estimated 68,000 cases each year, Japanese encephalitis (JE) is the leading cause of viral encephalitis in Asia. Vaccination against the disease is recommended for endemic populations and also for travelers at risk. Recently, a Vero cell-derived, inactivated, SA14-14-2 strain-based JE vaccine (JE-VC) became available for travelers from non-endemic regions, replacing the traditional mouse brain-derived vaccines. First licensed in 2009, JE-VC is currently available in Europe, the USA, Canada, Australia and several other countries. In 2013, the vaccine was approved by the European Medicines Agency and the US Food and Drug Administration for use in children. This review summarizes current data on the immunogenicity, safety and clinical use of JE-VC.
Keywords:
Ixiaro; JE-VC; Japanese encephalitis; Japanese encephalitis vaccine; immunogenicity; safety; traveler.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Chlorocebus aethiops
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Drug-Related Side Effects and Adverse Reactions / epidemiology
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Drug-Related Side Effects and Adverse Reactions / pathology
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Encephalitis, Japanese / epidemiology
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Encephalitis, Japanese / immunology
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Encephalitis, Japanese / prevention & control*
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Global Health
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Humans
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Japanese Encephalitis Vaccines / administration & dosage*
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Japanese Encephalitis Vaccines / adverse effects
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Japanese Encephalitis Vaccines / immunology*
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Japanese Encephalitis Vaccines / isolation & purification
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Technology, Pharmaceutical / methods
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Travel
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Vaccines, Inactivated / administration & dosage
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Vaccines, Inactivated / adverse effects
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Vaccines, Inactivated / immunology
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Vaccines, Inactivated / isolation & purification
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Vero Cells
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Virus Cultivation
Substances
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Japanese Encephalitis Vaccines
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Vaccines, Inactivated