Second line therapy in malignant pleural mesothelioma: A systematic review

Lung Cancer. 2015 Sep;89(3):223-31. doi: 10.1016/j.lungcan.2015.06.018. Epub 2015 Jun 23.


After the implementation of standard first line chemotherapy with platinum and antifolates in pleural mesothelioma, patients are confronted with a need for second line treatment at relapse or progression. We conducted a systematic review of the literature for the activity, effectiveness and toxicity of second line treatment. The results are presented according to the class of drugs: chemotherapy and targeted or biological agent.

Keywords: Biological; Chemotherapy; Mesothelioma; Meta-analysis; Outcome; Second line; Targeted treatment; Treatment.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Combined Modality Therapy
  • Humans
  • Lung Neoplasms / genetics
  • Lung Neoplasms / therapy*
  • Mesothelioma / genetics
  • Mesothelioma / therapy*
  • Mesothelioma, Malignant
  • Pleural Neoplasms / genetics
  • Pleural Neoplasms / therapy*
  • Retreatment
  • Treatment Outcome