Development of pharmaceutical clear gel based on Peceol®, lecithin, ethanol and water: Physicochemical characterization and stability study

J Colloid Interface Sci. 2015 Nov 1;457:152-61. doi: 10.1016/j.jcis.2015.06.010. Epub 2015 Jun 17.

Abstract

The phase behavior of the four-components Peceol®/lecithin/ethanol/water system has been studied in a part of the phase diagram poor in water and varying the lecithin/Peceol® ratio. Using several complementary techniques such as Karl Fischer titration, rheology, polarized microscopy and SAXS measurements several nanostructures of the complex systems were identified. W/O microemulsion (L2) as well as an inverted hexagonal (H2) liquid-crystal phase were studied. The analysis of the different phase transitions allows us to understand the effect of lecithin on the water solubilization efficiency of this clear gel and to show its pharmaceutical interest among lecithin organogels.

Keywords: Gel; Inverted hexagonal phase; Lecithin; Mono- di- tri-glycerides; Phase diagram; Polar lipids; W/O microemulsion.

MeSH terms

  • Chemistry, Physical
  • Ethanol / chemistry*
  • Gels / chemistry*
  • Lecithins / chemistry*
  • Liquid Crystals / chemistry
  • Nanostructures / chemistry
  • Oleic Acids / chemistry*
  • Water / chemistry*

Substances

  • Gels
  • Lecithins
  • Oleic Acids
  • Peceol
  • Water
  • Ethanol