Tobacco is a hard drug causing triple dependence. The medical management of tobacco smokers is thus complex and challenging. It requires a global approach combining non-pharmacological and pharmacological treatment. The general practitioner, having a privileged status, plays an important role. The recommended management is the strategy of the 5As (Ask, Advice, Assess, Assist, Arrange). This article proposes the management of tobacco smoking and cessation, in general practice, in the adult smoker, as well as the specificities of tobacco smoking and cessation in the pregnant woman and the teenager.