Chronic Cough

Arch Bronconeumol. 2015 Nov;51(11):579-89. doi: 10.1016/j.arbres.2015.03.019. Epub 2015 Jul 10.
[Article in English, Spanish]


Chronic cough (CC), or cough lasting more than 8 weeks, has attracted increased attention in recent years following advances that have changed opinions on the prevailing diagnostic and therapeutic triad in place since the 1970s. Suboptimal treatment results in two thirds of all cases, together with a new notion of CC as a peripheral and central hypersensitivity syndrome similar to chronic pain, have changed the approach to this common complaint in routine clinical practice. The peripheral receptors involved in CC are still a part of the diagnostic triad. However, both convergence of stimuli and central nervous system hypersensitivity are key factors in treatment success.

Keywords: Agentes antitusivos; Antittusive agents; Aspiración respiratoria; Cough; Disfunción de cuerdas vocales; Gastroesophageal reflux; Reflujo gastroesofágico; Respiratory aspiration; Tos; Vocal cord dysfunction.

Publication types

  • Practice Guideline

MeSH terms

  • Anti-Allergic Agents / therapeutic use
  • Anti-Infective Agents / therapeutic use
  • Antitussive Agents / therapeutic use
  • Chronic Disease
  • Cough* / diagnosis
  • Cough* / epidemiology
  • Cough* / etiology
  • Cough* / physiopathology
  • Cough* / therapy
  • Diagnostic Techniques, Respiratory System
  • Disease Management
  • Gastroesophageal Reflux / complications
  • Gastroesophageal Reflux / drug therapy
  • Gastrointestinal Agents / therapeutic use
  • Humans
  • Neural Pathways / physiopathology
  • Psychophysiologic Disorders / complications
  • Psychophysiologic Disorders / drug therapy
  • Psychotropic Drugs / therapeutic use
  • Respiratory Hypersensitivity / complications
  • Respiratory Hypersensitivity / drug therapy
  • Respiratory Tract Infections / complications
  • Respiratory Tract Infections / drug therapy
  • Sleep Apnea Syndromes / complications
  • Therapies, Investigational


  • Anti-Allergic Agents
  • Anti-Infective Agents
  • Antitussive Agents
  • Gastrointestinal Agents
  • Psychotropic Drugs