Sleep disorders and respiratory function in amyotrophic lateral sclerosis

Sleep Med Rev. 2016 Apr:26:33-42. doi: 10.1016/j.smrv.2015.05.007. Epub 2015 Jun 3.

Abstract

Sleep disorders in amyotrophic lateral sclerosis (ALS) present a significant challenge to the management of patients. Issues include the maintenance of adequate ventilatory status through techniques such as non-invasive ventilation, which has the ability to modulate survival and improve patient quality of life. Here, a multidisciplinary approach to the management of these disorders is reviewed, from concepts about the underlying neurobiological basis, through to current management approaches and future directions for research.

Keywords: Amyotrophic lateral sclerosis; Respiratory; Sleep; Ventilation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyotrophic Lateral Sclerosis / complications*
  • Amyotrophic Lateral Sclerosis / physiopathology
  • Disease Progression
  • Humans
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / physiopathology*
  • Respiratory Insufficiency / therapy
  • Sleep Wake Disorders / etiology
  • Sleep Wake Disorders / physiopathology*
  • Sleep Wake Disorders / therapy