FeNH4(SO4)2·12H2O (alum)-catalyzed preparation of 1,4-dihydropyridines: improved conditions for the Hantzsch reaction

Ali A Mohammadi; Armin Hadadzahmatkesh; Mohammad R Asghariganjeh

doi:10.1007/s00706-011-0672-6

FeNH₄(SO₄)₂·12H₂O (alum)-catalyzed preparation of 1,4-dihydropyridines: improved conditions for the Hantzsch reaction

Monatsh Chem. 2012;143(6):931-933. doi: 10.1007/s00706-011-0672-6. Epub 2011 Nov 17.

Authors

Ali A Mohammadi¹, Armin Hadadzahmatkesh¹, Mohammad R Asghariganjeh²

Affiliations

¹ Department of Chemistry, Sabzevar Branch, Islamic Azad University, Sabzevar, Iran.
² Department of Chemistry, Omidieh Branch, Islamic Azad University, Omidieh, Iran.

Abstract

Abstract: FeNH₄(SO₄)₂·12H₂O (alum) efficiently catalyzes the one-pot three-component reaction of dimedone, aldehydes, and 3-aminocrotonate to afford 1,4-dihydropyridines. The work-up is easy, and the products are obtained in good to excellent yields and high purity.

Keywords: 1,4-Dihydropyridines; FeNH4(SO4)2·12H2O; Hantzsch reaction; Multi-component reactions.