Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015;2015:760689.
doi: 10.1155/2015/760689. Epub 2015 Jun 16.

Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review With Clinical Application

Affiliations
Free PMC article
Review

Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review With Clinical Application

Romilly E Hodges et al. J Nutr Metab. .
Free PMC article

Abstract

Research into human biotransformation and elimination systems continues to evolve. Various clinical and in vivo studies have been undertaken to evaluate the effects of foods and food-derived components on the activity of detoxification pathways, including phase I cytochrome P450 enzymes, phase II conjugation enzymes, Nrf2 signaling, and metallothionein. This review summarizes the research in this area to date, highlighting the potential for foods and nutrients to support and/or modulate detoxification functions. Clinical applications to alter detoxification pathway activity and improve patient outcomes are considered, drawing on the growing understanding of the relationship between detoxification functions and different disease states, genetic polymorphisms, and drug-nutrient interactions. Some caution is recommended, however, due to the limitations of current research as well as indications that many nutrients exert biphasic, dose-dependent effects and that genetic polymorphisms may alter outcomes. A whole-foods approach may, therefore, be prudent.

Figures

Figure 1
Figure 1
Nrf2/Keap1 signaling (created from text in [154]).

Similar articles

See all similar articles

Cited by 16 articles

See all "Cited by" articles

References

    1. Baer-Dubowska W., Szaefer H. Modulation of carcinogen-metabolizing cytochromes P450 by phytochemicals in humans. Expert Opinion on Drug Metabolism and Toxicology. 2013;9(8):927–941. doi: 10.1517/17425255.2013.795219. - DOI - PubMed
    1. Steinkellner H., Rabot S., Freywald C., et al. Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutation Research. 2001;480-481:285–297. doi: 10.1016/s0027-5107(01)00188-9. - DOI - PubMed
    1. Moon Y. J., Wang X., Morris M. E. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicology in Vitro. 2006;20(2):187–210. doi: 10.1016/j.tiv.2005.06.048. - DOI - PubMed
    1. Hakooz N., Hamdan I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Current Drug Metabolism. 2007;8(1):9–15. doi: 10.2174/138920007779315080. - DOI - PubMed
    1. James D., Devaraj S., Bellur P., Lakkanna S., Vicini J., Boddupalli S. Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition Reviews. 2012;70(11):654–665. doi: 10.1111/j.1753-4887.2012.00532.x. - DOI - PubMed

LinkOut - more resources

Feedback