Abstract
(+)-Zincophorin methyl ester is prepared in 13 steps (longest linear sequence). A bidirectional redox-triggered double anti-crotylation of 2-methyl-1,3-propane diol directly assembles the triketide stereopolyad spanning C4-C12, significantly enhancing step economy and enabling construction of (+)-zincophorin methyl ester in nearly half the steps previously required.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Carboxylic Acids / chemical synthesis*
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Carboxylic Acids / chemistry
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Ionophores / chemical synthesis*
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Ionophores / chemistry
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Oxidation-Reduction
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Polyketides / chemical synthesis
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Polyketides / chemistry
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Propylene Glycols / chemical synthesis
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Propylene Glycols / chemistry
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Stereoisomerism
Substances
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Carboxylic Acids
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Ionophores
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Polyketides
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Propylene Glycols
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zincophorin methyl ester
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2-methyl-1,3-propanediol