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Review
. 2015 Jul 20;128(14):1969-76.
doi: 10.4103/0366-6999.160566.

New Delhi Metallo-β-Lactamase-Mediated Carbapenem Resistance: Origin, Diagnosis, Treatment and Public Health Concern

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Free PMC article
Review

New Delhi Metallo-β-Lactamase-Mediated Carbapenem Resistance: Origin, Diagnosis, Treatment and Public Health Concern

Wen-Juan Wei et al. Chin Med J (Engl). .
Free PMC article

Abstract

Objective: To review the origin, diagnosis, treatment and public health concern of New Delhi metallo-β-lactamase (NDM)-producing bacteria.

Data sources: We searched database for studies published in English. The database of PubMed from 2007 to 2015 was used to conduct a search using the keyword term "NDM and Acinetobacter or Enterobacteriaceae or Pseudomonas aeruginosa."

Study selection: We collected data including the relevant articles on international transmission, testing methods and treatment strategies of NDM-positive bacteria. Worldwide NDM cases were reviewed based on 22 case reports.

Results: The first documented case of infection caused by bacteria producing NDM-1 occurred in India, in 2008. Since then, 13 blaNDM variants have been reported. The rise of NDM is not only due to its high rate of genetic transfer among unrelated bacterial species, but also to human factors such as travel, sanitation and food production and preparation. With limited treatment options, scientists try to improve available therapies and create new ones.

Conclusions: In order to slow down the spread of these NDM-positive bacteria, a series of measures must be implemented. The creation and transmission of blaNDM are potentially global health issues, which are not issues for one country or one medical community, but for global priorities in general and for individual wound care practitioners specifically.

Conflict of interest statement

Conflict of Interest: None declared.

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References

    1. Salcido RS. Super bugs: Survival of the fittest. Adv Skin Wound Care. 2010;23:439. - PubMed
    1. Johnson AP, Woodford N. Global spread of antibiotic resistance: The example of New Delhi metallo-ß-lactamase (NDM)-mediated carbapenem resistance. J Med Microbiol. 2013;62(Pt 4):499–513. - PubMed
    1. Webster PC. Global action urged in response to new breed of drug-resistant bacteria. CMAJ. 2010;182:1602–3. - PMC - PubMed
    1. Rogers BA, Sidjabat HE, Silvey A, Anderson TL, Perera S, Li J, et al. Treatment options for New Delhi metallo-beta-lactamase-harboring Enterobacteriaceae. Microb Drug Resist. 2013;19:100–3. - PubMed
    1. El-Herte RI, Kanj SS, Matar GM, Araj GF. The threat of carbapenem-resistant Enterobacteriaceae in Lebanon: An update on the regional and local epidemiology. J Infect Public Health. 2012;5:233–43. - PubMed

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