1 Academic Respiratory Unit, School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol BS10 5NB UK.
2 Oxford Respiratory Trials Unit, Oxford Centre for Respiratory Medicine, Oxford University Hospitals, Churchill site, Oxford, UK.
3 Academic Respiratory Unit, School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol BS10 5NB UK. Electronic address: nick.maskell@bristol.ac.uk.