[Optical and electron microscopic study of the kidney of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi]

Rev Inst Med Trop Sao Paulo. May-Jun 1989;31(3):139-45. doi: 10.1590/s0036-46651989000300002.
[Article in Portuguese]


Two naturally infected dogs (male and female) from Teófilo Otoni (MG-Brazil) were maintained for 18 months in our laboratory. Two other dogs, two months old males were infected with 1 x 10(6) promastigotes of MHO/BR/70/BH46 Leishmania (Leishmania) chagasi strain, endovenous route, and autopsied after 10 months and two years. The main findings concerning the kidney were: (1) focal or diffuse mesangial glomerulonephritis with proliferative and enlargement of mesangial cells; (2) increase in thickness of basement membrane with electron-dense deposits; (3) chronic interstitial nephritis with intense exudation of plasmocytes; (4) cloud swelling of renal tubules. The authors discuss the probable pathogenetic mechanisms.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Dogs
  • Female
  • Glomerulonephritis, Membranoproliferative / etiology*
  • Kidney / pathology
  • Kidney / ultrastructure*
  • Leishmaniasis, Visceral / complications*
  • Male
  • Nephritis, Interstitial / etiology*