Platelet-Rich Plasma with Basic Fibroblast Growth Factor for Treatment of Wrinkles and Depressed Areas of the Skin

Plast Reconstr Surg. 2015 Nov;136(5):931-939. doi: 10.1097/PRS.0000000000001705.


Background: There are several treatments for wrinkles and depressed areas of the face, hands, and body. Hyaluronic acid is effective, but only for 6 months to 1 year. Autologous fat grafting may cause damage during tissue harvest.

Methods: In this study, patients were injected with platelet-rich plasma plus basic fibroblast growth factor (bFGF). Platelet-rich plasma was prepared by collecting blood and extracting platelets using double centrifugation. Basic fibroblast growth factor diluted with normal saline was added to platelet-rich plasma. There were 2005 patients who received platelet-rich plasma plus bFGF therapy.

Results: Of the 2005 patients treated, 1889 were female and 116 were male patients; patients had a mean age of 48.2 years. Treated areas inlcuded 1461 nasolabial folds, 437 marionette lines, 1413 nasojugal grooves, 148 supraorbital grooves, 253 midcheek grooves, 304 foreheads, 49 temples, and 282 glabellae. Results on the Global Aesthetic Improvement Scale indicated that the level of patient satisfaction was 97.3 percent and the level of investigator satisfaction was 98.4 percent. The period for the therapy's effectiveness to become apparent was an average of 65.4 days. Platelet-rich plasma plus bFGF therapy resulted in an improved grade on the Wrinkle Severity Rating Scale. Improvement was 0.55 for a Wrinkle Severity Rating Scale grade of 2, 1.13 for a Wrinkle Severity Rating Scale grade of 3, 1.82 for a Wrinkle Severity Rating Scale grade of 4, and 2.23 for a Wrinkle Severity Rating Scale grade of 5.

Conclusions: Platelet-rich plasma plus bFGF is effective in treating wrinkles and depressed areas of the skin of the face and body. The study revealed that platelet-rich plasma plus bFGF is an innovative therapy that causes minimal complications.

Clincal question/level of evidence: Therapeutic, IV.

MeSH terms

  • Aged
  • Cohort Studies
  • Combined Modality Therapy
  • Esthetics*
  • Female
  • Fibroblast Growth Factor 2 / therapeutic use*
  • Follow-Up Studies
  • Humans
  • Injections, Intradermal
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Nasolabial Fold
  • Patient Satisfaction / statistics & numerical data
  • Platelet-Rich Plasma*
  • Retrospective Studies
  • Skin / drug effects
  • Skin / physiopathology*
  • Skin Aging / drug effects*
  • Skin Aging / physiology
  • Statistics, Nonparametric
  • Treatment Outcome


  • Fibroblast Growth Factor 2