Synthesis, characterization and study of antioxidant activity of quercetin-magnesium complex

Spectrochim Acta A Mol Biomol Spectrosc. 2015 Dec 5;151:807-13. doi: 10.1016/j.saa.2015.07.050. Epub 2015 Jul 9.


Quercetin (3,3',4',5,7-pentahydroxyflavone) one of the most abundant dietary flavonoids, has been investigated in the presence of magnesium (II) in methanol. The complex formation between quercetin and magnesium (II) was examined under UV-visible, Infra-red and (1)H NMR spectroscopic techniques. The spectroscopic data denoted that quercetin can reacts with magnesium cation (Mg(+2)) through the chelation site in the quercetin molecule. The free radical antioxidant activity of the complex with respect to the parent molecule was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. It was observed that the free radical scavenging activity of quercetin was increased after complexation of magnesium (Mg(+2)) cation.

Keywords: Antioxidant activity; Flavonoids; Quercetin; Quercetin–magnesium complex; Radical scavenging activity; Spectral characterisation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemical synthesis
  • Antioxidants / chemistry*
  • Antioxidants / pharmacology*
  • Biphenyl Compounds / chemistry
  • Chelating Agents / chemistry
  • Chemistry Techniques, Synthetic
  • Free Radical Scavengers / chemistry
  • Magnesium / chemistry*
  • Magnesium / pharmacology
  • Magnetic Resonance Spectroscopy
  • Microscopy, Electron, Scanning
  • Picrates / chemistry
  • Quercetin / chemistry*
  • Quercetin / pharmacology
  • Spectrophotometry, Ultraviolet
  • X-Ray Diffraction


  • Antioxidants
  • Biphenyl Compounds
  • Chelating Agents
  • Free Radical Scavengers
  • Picrates
  • Quercetin
  • 1,1-diphenyl-2-picrylhydrazyl
  • Magnesium