Effects of Lonicera japonica Thunb. on Type 2 Diabetes via PPAR-γ Activation in Rats

Phytother Res. 2015 Oct;29(10):1616-21. doi: 10.1002/ptr.5413. Epub 2015 Jul 14.


Lonicera japonica Thunb. (Caprifoliaceae) is a traditional herbal medicine and has been used to treat diabetic symptoms. Notwithstanding its use, the scientific basis on anti-diabetic properties of L. japonica is not yet established. This study is designed to investigate anti-diabetic effects of L. japonica in type 2 diabetic rats. L. japonica was orally administered at the dose of 100 mg/kg in high-fat diet-fed and low-dose streptozotocin-induced rats. After the treatment of 4 weeks, L. japonica reduced high blood glucose level and homeostatic model assessment of insulin resistance in diabetic rats. In addition, body weight and food intake were restored by the L. japonica treatment. In the histopathologic examination, the amelioration of damaged β-islet in pancreas was observed in L. japonica-treated diabetic rats. The administration of L. japonica elevated peroxisome proliferator-activated receptor gamma and insulin receptor subunit-1 protein expressions. The results demonstrated that L. japonica had anti-diabetic effects in type 2 diabetic rats via the peroxisome proliferator-activated receptor gamma regulatory action of L. japonica as a potential mechanism.

Keywords: Lonicera japonica Thunb; PPAR-γ; anti-diabetic; anti-hyperglycemic; type 2 diabetes mellitus.

MeSH terms

  • Animals
  • Body Weight
  • Diabetes Mellitus, Experimental / drug therapy
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Diet, High-Fat
  • Hyperglycemia / drug therapy
  • Insulin Resistance
  • Lonicera*
  • Male
  • PPAR gamma / metabolism*
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Plants, Medicinal
  • Rats
  • Streptozocin


  • PPAR gamma
  • Plant Extracts
  • Streptozocin