Development and functions of the choroid plexus-cerebrospinal fluid system

Nat Rev Neurosci. 2015 Aug;16(8):445-57. doi: 10.1038/nrn3921. Epub 2015 Jul 15.


The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates. Various animal models have provided insights into how the ChP-CSF system develops and matures. In addition, recent studies have uncovered new, active roles for this dynamic system in the regulation of neural stem cells, critical periods and the overall health of the nervous system. Together, these findings have brought about a paradigm shift in our understanding of brain development and health, and have stimulated new initiatives for the treatment of neurological disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cerebrospinal Fluid / physiology*
  • Choroid Plexus / growth & development*
  • Choroid Plexus / physiology*
  • Humans