Genetic Classification of Gliomas: Refining Histopathology

Cancer Cell. 2015 Jul 13;28(1):9-11. doi: 10.1016/j.ccell.2015.06.014.


Newly published studies validate prior reports that specific combinations of genetic alternations in IDH1/2, ATRX, TERT, TP53, and co-deletion of 1p/19q have the ability to reclassify gliomas into rational subsets, defining a glioma's biological and clinical behavior more accurately than stratifications based solely on histopathology.

MeSH terms

  • Biomarkers, Tumor / genetics*
  • Brain Neoplasms / genetics
  • Brain Neoplasms / pathology*
  • Genomic Instability
  • Glioma / genetics
  • Glioma / pathology*
  • Humans
  • Prognosis


  • Biomarkers, Tumor